Product Information

The SampleSense prepFAST described in this application note automatically calibrates, dilutes and spikes samples, and adjusts sample loading for variable sample volume and viscosity to improve efficiency, consistency, and performance for the analysis of pharmaceutical products.

Metal impurities need to be determined in organic solvents used in pharmaceuticals production, electronics manufacturing, food oil or fat extraction, and many other applications. ICP is an excellent choice for ppb level detection of metals in organic solvents. This note demonstrates a specialized automation and sample introduction system optimized for organic solvents analysis using a sequential ICP detector.

The prepFAST inline autodilution system with ICP-MS fully automates USP <233> sample dilutions and J based calibrations. The prepFAST automatically 1) dilutes a single stock standard to build linear calibration curves surpassing all USP<233> validation criteria and 2) dilutes samples to the appropriate Total Dissolved Solids (TDS).

The prepFAST inline autodilution system with ICPMS fully automates USP <233> sample dilutions and J based calibrations. The prepFAST automatically 1) dilutes a single stock standard to build linear calibration curves and 2) dilutes samples to the appropriate Total Dissolved Solids (TDS) surpassing all USP <233> validation criteria.

The International Committee on Harmonization has released a Q3D document on elemental impurities in pharmaceutical products. This document contains updates to elements for analysis and Permissible Daily Dose (PDE) levels. Calibrations at 0.5J and 2J for the new elements and levels show excellent linearity (>0.999), demonstrating the robustness of the prepFAST and the ability to adapt to changing industry regulations.

The prepFAST inline autodilution system with ICP-OES fully automates USP <233> J based calibrations protocols. The prepFAST provides 1) autocalibration, 2) autosample injection, and 3) autospike addition, eliminating manual sample preparation.

The prepFAST inline autodilution system with ICP and ICP-MS, fully automates USP <233> methods. The prepFAST can 1) dilute a single stock standard to build linear calibration curves, 2) dilute samples to the appropriate TDS and 3) spikes samples at user defined J values.