Clinical laboratories can analyze hundreds or even thousands of samples per day. For this level of volume to be achieved, high-throughput methods with instrumentation capable of handling this extreme sample load must be maintained to provide fast, reliable, and accurate results. ESI offers the SampleSense Clinical system, which is an extremely fast sample-to-sample solution for ICP and ICPMS without compromising reliability or accuracy.
SampleSense 6 Port Valve with Dual Optical Sensors
|2F-SS6-UHTC||SampleSense FAST Clinical 2DXCi|
|4F-SS6-UHTC||SampleSense FAST Clinical 4DXCi|
|8F-SS6-UHTC||SampleSense FAST Clinical 8DXCi|
|14F-SS6-UHTC||SampleSense FAST Clinical 14DXCi|
*Autosampler model may be dependant on ICPMS. Contact your ESI representative for more information.
Achieving rapid throughput without sacrificing stability requires excellent washout between samples. The SampleSense Clinical setup utilizes a trapping valve to enhance washout. This valve traps rinse solution in the probe and immediately rinses the loop after the ICPMS data acquisition is complete,using minimal rinse solution while still achieving > 1000x washout after a 100 μg/dL Pb standard.
The SampleSense FAST Clinical was used to analyze 576 bovine blood samples (50x dilution) located in six 96-well microtiter plates in a single analytical run with extremely stable results (<1% RSD). This level of performance is unmatched by any clinical system on the market.
The SampleSense Clinical system is available with a range of autosampler models to suit customer requirements. The 2DXi and 4DXi models can accommodate micro- and microtitre racks in addition to standard sized test tube racks.Example of a 4DXCi Configuration
Close up of the probe inserted into one of the wells of a 96 well microtiter plate with 2 mL of diluted blood per location, enough to perform a repeat analysis (using a 500 μL sample loop) if required.
Sample integrity is an important consideration for high-throughput methods and cannot be ignored or compromised for speed. To that end, the SampleSense FAST Clinical can ensure the integrity of the sample results in two critical ways. First, every failed event (unsensed sample loading or rinse) is logged by the ESI software (in an Excel spreadsheet for easy exporting) and displayed on the computer screen for the analyst. Secondly, as additional confirmation of a missed sample in the raw ICPMS data, a marker component can be added to the carrier solution. If a sample fails to load correctly, SampleSense automatically responds by triggering the ICPMS analysis without injecting the sample loop contents, resulting in the analysis of the marked carrier solution. The presence of this marker can be monitored to provide additional confirmation to the analyst that a specific sample was not introduced successfully.